公告(公開)號

專利名稱

US5753265

Multiple unit pharmaceutical preparation

申請日／公告日

申請人（國家）

1995/06/07／1998/05/19

Astra Aktiebolag (Sodertalje, SE)

摘要

A new pharmaceutical multiple unit tableted dosage form containing as active ingredient an acid labile H.sup.+ K.sup.+ -ATPase inhibitor or an alkaline salt thereof or one of its single enantiomers or an alkaline salt thereof, a method for the manufacture of such a formulation, and the method of treatment with such a formulation in medicine.

專利範圍第一項或其他相關之專利範圍

1. An oral pharmaceutical composition in the form of a multiple unit tablet comprising:

a tablet excipient;

a multiple of a core unit comprising as an active ingredient an acid-labile H.sup.+ K.sup.+ -ATPase inhibitor compound in a neutral form or a salt form, a single enantiomer or an alkaline salt of a single enantiomer;

the core unit being covered with at least one enteric coating layer having mechanical properties so as not to significantly affect the acid resistance of the enteric coating layered unit by compression during tableting.

公告(公開)號／被引證次數

專利名稱

US5817338／64次

Multiple unit tableted dosage form of omeprazole

申請日／公告日

申請人（國家）

1995/06/07／1998/10/06

Astra Aktiebolag (Sodertalje, SE)

摘要

A new pharmaceutical multiple unit tableted dosage form containing omeprazole or one of its single enantiomers or an alkaline salt of omeprazole or one of its single enantiomers, a method for the manufacture of such a formulation, and the use of such a formulation in medicine.

專利範圍第一項或其他相關之專利範圍

1. A pharmaceutical multiple unit tablet composition for oral treatment of gastrointestinal disorder comprising:

at least one tablet excipient; and

a multiple of a pellet or granule, the pellet or granule ranging between 0.1 mm and 2 mm in size and comprising an active ingredient selected from the group consisting of omeprazole, a single enantiomer of omeprazole, an alkaline salt of omeprazole, and an alkaline salt of a single enantiomer of omeprazole; and the pellet or granule being covered with at least one enteric coating layer comprising a plasticizing compound in the amount of more than about 20% to less than about 50% by weight of the enteric coating layer polymer so as to minimize the reduction of acid resistance of the enteric coating layered units upon compression into the tablet form.

公告(公開)號／被引證次數

專利名稱

US5599794／36次

Synergistic combination of a substance with gastric acid secretion inhibiting effect and an acid degradable antibiotic

申請日／公告日

申請人（國家）

1993/04/22／1997/02/04

ASTRA AB

摘要

The invention consists of a combination of a substance that increases the intragastric pH and an acid degradable antibacterial compound. By this combined product regimen it will be possible to obtain maximal local antibacterial effect of acid degradable antibiotics as well as enhanced bioavailability of the active antibiotic, thus resulting in higher amounts of the active compound in the gastric mucosa due to secretion of weak bases. Both pharmacological effects contribute to drastically increased antimicrobial capacity of acid degradable antibiotics to be used against local infections in the gastrointestinal tract causing gastritis and/or peptic ulcer. The invention also selects to the use of said combination and a process for the preparation thereof.

專利範圍第一項或其他相關之專利範圍

1. A synergistic combination comprising from about 1-200 mg omeprazole or a pharmaceutically acceptable salt thereof and from about 250 mg to 10 mg clarithromycin for the treatment of gastritis and peptic ulcer.